I have been using Watir on and off for quite a long time, seeing it develop from Watir through Watir-Webdriver and back to Watir. I needed to install its latest incarnation and hit a few problems. The problems were caused more by my impatience in not reading through the notes on the Watir website than anything else.
At the same time, I decided to install the Python Selenium package to try it out. It also didn't work out of the box. Once again, the problem was that I hadn't been sufficiently thorough in reading the instructions.
The main problem with both was the need to install the Firefox and Chrome web drivers and to configure Safari's. After a little trial and error and reading through the documents, the simplest way came to the surface.
brew install chromedriver
My Safari installation was already configured to show the Develop menu and I have Allow Remote Automation menu item selected. From the Watir Safari Driver page, I found that I need to run safaridriver once from the command line to give it the proper authorities. I needed to run it from an administrator account:
sudo /usr/bin/safaridriver
After that both Watir and Python Selenium both will happily load Safari, Firefox and Chrome when run from a macOS user account.